Cryo-EM structure of cystinosin in a cytosol-open state
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8dke
Q-score: 0.532
Guo X, Schmiege P, Assafa TE, Wang R, Xu Y, Donnelly L, Fine M, Ni X, Jiang J, Millhauser G, Feng L, Li X
Cell (2022) 185 pp. 3739-3752.e18 [ DOI: doi:10.1016/j.cell.2022.08.020 Pubmed: 36113465 ]
- Cystinosin-fab 3h5 complex in cytosol-open conformation (Complex)
- Cystinosin (Complex from Homo sapiens)
- Isoform 2 of cystinosin (46 kDa, Protein from Homo sapiens)
- Fab 3h5 kappa chain (25 kDa, Protein from Mus musculus)
- Fab 3h5 heavy chain (26 kDa, Protein from Mus musculus)
- Fab 3h5 (Complex from Mus musculus)
Cryo-EM structure of cystinosin in a lumen-open state
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8dki
Q-score: 0.497
Guo X, Schmiege P, Assafa TE, Wang R, Xu Y, Donnelly L, Fine M, Ni X, Jiang J, Millhauser G, Feng L, Li X
Cell (2022) 185 pp. 3739-3752.e18 [ DOI: doi:10.1016/j.cell.2022.08.020 Pubmed: 36113465 ]
- Cystinosin (Complex from Homo sapiens)
- Isoform 2 of cystinosin (46 kDa, Protein from Homo sapiens)
- Fab 3h5 kappa chain (25 kDa, Protein from Mus musculus)
- Cystinosin-fab 3h5 complex in lumen-open conformation (Complex)
- Fab 3h5 (Complex from Mus musculus)
- Fab 3h5 heavy chain (26 kDa, Protein from Mus musculus)
Cryo-EM structure of cystine-bound cystinosin in a lumen-open state
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8dkm
Q-score: 0.51
Guo X, Schmiege P, Assafa TE, Wang R, Xu Y, Donnelly L, Fine M, Ni X, Jiang J, Millhauser G, Feng L, Li X
Cell (2022) 185 pp. 3739-3752.e18 [ DOI: doi:10.1016/j.cell.2022.08.020 Pubmed: 36113465 ]
- Cystinosin (Complex from Homo sapiens)
- Fab 3h5 kappa chain (25 kDa, Protein from Mus musculus)
- Isoform 2 of cystinosin (46 kDa, Protein from Homo sapiens)
- L-cystine (240 Da, Ligand)
- Fab 3h5 (Complex from Mus musculus)
- Cystinosin-fab 3h5 complex with cystine bound in a lumen-open conformation (Complex from Homo sapiens)
- Fab 3h5 heavy chain (26 kDa, Protein from Mus musculus)
Cryo-EM structure of cystinosin N288K mutant in a cytosol-open state at pH5.0
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8dkw
Q-score: 0.522
Guo X, Schmiege P, Assafa TE, Wang R, Xu Y, Donnelly L, Fine M, Ni X, Jiang J, Millhauser G, Feng L, Li X
Cell (2022) 185 pp. 3739-3752.e18 [ DOI: doi:10.1016/j.cell.2022.08.020 Pubmed: 36113465 ]
- Cystinosin n288k - fab 3h5 complex at ph5.0 (Complex)
- Fab 3h5 kappa chain (25 kDa, Protein from Mus musculus)
- Isoform 2 of cystinosin (46 kDa, Protein from Homo sapiens)
- Cystinosin n288k (Complex from Homo sapiens)
- Fab 3h5 (Complex from Mus musculus)
- Fab 3h5 heavy chain (26 kDa, Protein from Mus musculus)
Cryo-EM structure of cystinosin N288K mutant in a cytosol-open state at pH7.5
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8dkx
Q-score: 0.542
Guo X, Schmiege P, Assafa TE, Wang R, Xu Y, Donnelly L, Fine M, Ni X, Jiang J, Millhauser G, Feng L, Li X
Cell (2022) 185 pp. 3739-3752.e18 [ DOI: doi:10.1016/j.cell.2022.08.020 Pubmed: 36113465 ]
- Fab 3h5 kappa chain (25 kDa, Protein from Mus musculus)
- Isoform 2 of cystinosin (46 kDa, Protein from Homo sapiens)
- Cystinosin n288k (Complex from Homo sapiens)
- Fab 3h5 (Complex from Mus musculus)
- Cystinosin n288k - fab 3h5 complex at ph7.5 (Complex)
- Fab 3h5 heavy chain (26 kDa, Protein from Mus musculus)
Structure of human TRPML1 with ML-SI3
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7mgl
Q-score: 0.558
Structure (2021) 29 pp. 1295-1302.e3 [ Pubmed: 34171299 DOI: doi:10.1016/j.str.2021.06.003 ]
- Mucolipin-1 (65 kDa, Protein from Homo sapiens)
- Trpml1 complex with ml-si3 (Complex from Homo sapiens)
- N-{(1s,2s)-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl}benzenesulfonamide (429 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
Structure of M-6-P/IGFII Receptor at pH 4.5
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 6um1
Q-score: 0.401
Wang R, Qi X, Schmiege P, Coutavas E, Li X
Sci Adv (2020) 6 pp. eaaz1466- [ DOI: doi:10.1126/sciadv.aaz1466 ]
- Igfiir (Complex from Bos taurus)
- Cation-independent mannose-6-phosphate receptor (274 kDa, Protein from Bovine)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of M-6-P/IGFII Receptor and IGFII complex
Resolution: 4.32 Å
EM Method: Single-particle
Fitted PDBs: 6um2
Q-score: 0.356
Wang R, Qi X, Schmiege P, Coutavas E, Li X
Sci Adv (2020) 6 pp. eaaz1466- [ DOI: doi:10.1126/sciadv.aaz1466 ]
- Insulin-like growth factor ii (Complex from Homo sapiens)
- Igfiir and igfii complex (Complex)
- Insulin-like growth factor ii (7 kDa, Protein from Homo sapiens)
- Cation-independent mannose-6-phosphate receptor (274 kDa, Protein from Bovine)
- Cation-independent mannose-6-phosphate receptor (Complex from Bos taurus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
cryo-EM structure of human TRPML1 with PI35P2
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6e7p
Q-score: 0.447
Nat Commun (2018) 9 pp. 4192-4192 [ DOI: doi:10.1038/s41467-018-06493-7 Pubmed: 30305615 ]
cryo-EM structure of human TRPML1 with PI45P2
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 6e7y
Q-score: 0.431
Nat Commun (2018) 9 pp. 4192-4192 [ DOI: doi:10.1038/s41467-018-06493-7 Pubmed: 30305615 ]